Do you have an entrepreneurial spirit and/or business AND desire a home in the Downingtown (East) School District, close to Rtes 100/113/202/PA Turnpike, trains, parks, shops, dining? Welcome to 529 W. Uwchlan Avenue! This distinctive property includes BOTH a wonderful RESIDENCE with spacious sun-filled living areas; upgraded amenities including hardwood floors and a redesigned epicurean kitchen; multiple decks, privacy fence, and flat, grassy yards..AND also a commercial BUSINESS space that is perfect for your flexible live/work lifestyle. The residence includes an etched glass front door entry into a tiled Foyer/Mudroom. There is a Breakfast Room that leads into the fabulous redesigned Kitchen with raised-panel antique white Thomasville 42" cabinetry & curios; upgraded stainless steel appliances; double sink; and Silestone quartz counters. The huge Family Room has both a mantled wood fireplace and vent-free gas fireplace stove, and is adjacent to the formal Dining Room with bumped-out bay window, wood fireplace, and elegant tray ceiling. Stylish double doors lead into the oversized Living Room that includes a cozy wood fireplace with brick hearth. This first floor includes one of the two Master Suites, with large Bedroom, Full Bath, and three closets. Up the millwork-accented staircase to the second floor, and there is the other Master Suite with gleaming hardwood floors; a door out to an elevated balcony; Full Bath; wall of closets; vent-free gas fireplace stove; and a Sitting Room that could also function as a 5th Bedroom w/large closet. Down the hall are 2 more Bedrooms; Bonus Room/Study; and incredible 31x29 Walk-in Storage Room that is your ultimate dream closet! Also on this level is more storage; one of the two Laundry Rooms (other in the basement) that is paired with a Half Bath (potential to add a shower); and a back staircase to another Full Bath. Outside enjoy a bucolic setting of mature trees, blooming gardens, and flat, grassy yards PLUS multi-level Decks & a private fenced area. On to the business side of the building, with handicap accessible parking & entrances; multiple reception areas; 2 Half Baths; 6 small Offices (exam rooms) all plumbed with sinks; a Study/Den; extended 31x7 Storage Room & additional storage closets; more! The partially Finished Basement includes a Bonus Room; more storage; and a resort-style indoor/in-ground Sylvan pool (not currently filled) in a private room with windows & slider doors out to the Patio and the back yard. Do not miss the oversized 2-Car Garage plus outdoor paved parking for 15+ vehicles. Designed for energy efficiency with its convenient 7 heating & A/C zones divided between the residence and business area. So perfect for your current home business or innovative business plans --- potential as space for lawyer, doctor, dentist, architect, planner, engineer, financial consultant, insurance agent, accountant, computer programming, tutoring, beautician/barber services, dress making/tailoring, artisans or home crafts, home cooking/catering, service businesses, more! Must contact Uwchlan Township for more details and information about R61 Mixed Use/Code 602 Home Occupation Overlay (summary sheet uploaded on the MLS). Some photos virtually staged.